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KMID : 0861020040190010001
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Korea Journal of Herbology
2004 Volume.19 No. 1 p.1 ~ p.11
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A Efficacy of Ginseng Radix On Prevention of Osteoporosis In Ovariectomized Rats
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정국영/Jung, Kuk-Young
서부일/이은숙/변부형/신순식/박지하/Seo, Bu-Il/Lee, Eun-Sook/Byun, Boo-Hyeong/Shin, Soon-Shik/Park, Ji-Ha
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Abstract
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Objectives : The present study has been undertaken to investigate the effects of Ginseng Radix on prevention of osteoporosis in ovariectomized rats.
Methods : In this experiment, the rats were ovariectomized. Rats were administered by 2 kinds of medicine, Estradiol, Ginseng Radix. The levels of bone mineral density, osteocalcin, ALP, phosphorus, calcium in serum, deoxypyridinoline in urine, calcium, phosphorus, ash weight of bone, body weight and uterus weight were measured.
Results : The levels of spinal bone mineral density was significantly increased in comparison with OVX group at 8 weeks in Ginseng Radix group.
The levels of serum didn t show significant change in comparison with OVX group in Ginseng Radix group.
The levels of urine deoxypyridinoline showed significant decrease in comparison with OVX group in Ginseng Radix group.
The levels of femoral and fibula-tibial ash weight didn t show significant increase in comparison with OVX group in Ginseng Radix group. The levels of femoral and fibula-tibial calcium showed significant increase in comparison with OVX group in Ginseng Radix group. The levels of femoral and fibula-tibial phosphorus showed significant increase in comparison with OVX group in Ginseng Radix group.
The levels of body weight didn t show significant changes in comparison with OVX group in Ginseng Radix group. The levels of uterus weight didn t show significant changes in comparison with OVX group in Ginseng Radix group.
Conclusions : Reviewing these experimetal results, it appears that Ginseng Radix have efficacy on prevention of osteoporosis. And further study should be conducted to illustrate in depth the curing and prevention of osteoprosis.
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KEYWORD
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